bremelanotide

A long time ago, in May 2008, I wrote about how PL-6983 is the new version of Bremelanotide after the FDA shot down Palatin Technologies research with Bremelanotide (as a drug for ED and FSD administered with a nasal mist)…

But as it turns out, Palatin Technologies is *still* working on Bremelanotide, except instead of “sniffing” it, a person would inject it into themselves similar to how some Diabetics do injections. Note this does NOT mean injecting Brem into a blood vessel/stream! 

And this week Palatin Technologies published results of the most recent tests with Brem administered in this fashion – and it was GOOD news.   They reported patients reacted similar to those who tried Brem nasally in their old tests but WITHOUT the possible nausea and increased blood pressure that was used by the FDA to stop approval for Bremelanotide when taken the old way.

So now Palatin will go ahead with the next stage of clinical trials (stage 2b) and HOPEFULLY it’ll be available by prescription for people experiencing either erectile disorder or female sexual arousal disorder!

From the press release, here are the offical results of these latest trials:

Key Results

In all subjects, subcutaneous administration of bremelanotide resulted in consistent and predictable plasma concentrations at levels known from previous studies to improve erectile function. Other key results include:

• No statistically significant difference in mean changes in blood pressure was seen in subjects receiving bremelanotide compared to placebo.
• No clinically or statistically significant difference in the range of blood pressure changes was seen in subjects receiving bremelanotide compared to placebo.
• No subject discontinued participation in the study as a result of protocol stopping rules based on blood pressure changes.
• No subject discontinued participation in the study due to nausea.
• No difference in the rate of vomiting observed between subjects receiving bremelanotide compared to placebo (one in each group).

Full press release here.

Stay tuned – I’ll post more when I see it (ie if/when they start those stage 2b trials).

~ Ciao

As I mentioned in my last post here about the "Female Viagra" documentary, that W-Five News Magazine show is on tonight at pm (CTV in Canada, December 6).

I'll post a summary sometime after th show, for the benefit of people outside Canada who can't watch it, but for now you can check out this short preview / interview  on CTV's website from that station's Morning Show…

‘Pharma Sutra,’ a CTV original documentary, takes a closer look a the multi-billion-dollar race for the female Viagra.

http://watch.ctv.ca/news/top-picks/pharma-sutra-preview/#clip119032

Hey,

I just saw some news that a Canadian documentary show called W5 is showing a film called "Pharma Sutra" that's all about new "female viagras" being developed for Female Sexual Arousal Disorder (FSAD).

It also interviews some women  who are experiencing that condition and will certainly feature other news and information of interest.  One new product the show will apparently talk about is a nasal spray, which is certainly Bremelanotide – which Palatin Technologies has tweaked to create a new similar drug called PL-6983… which I'm sure they'll give a real name to soon, since Bremelanotide likewise use to be called PT-141. 

There will be an update here soon after the documentary is shown on Saturday December 6, 2008 on the CTV channel is Canada….

You can read more about Bremelanotide and/or sign up for the "Bremelanotide Bulletin" here:

http://www.bremolanotide.com 

There's also a website about PL-6983 with a sign up form for upcoming information here:

http://www.pl-6983.com 

The 'Pharma Sutra' documentary was created by a company called Cogent / Benger Productions here:

http://www.cogentbenger.com/index.php 

Palatin Technologies is developing PL-6983 and their website is here: 

http:www.palatin.com

I haven't added an entry for quite some time, but have been following all the news about Bremelanotide over these months.. and now I should change the name of my blog from "Bremelanotide" to "PL-6983"..!

Palatin Technologies, the company that was testing Bremelanotide to treat sexual arousal disorders for men and women, announced this month that they were stopping their research with Brem (technically they are switching to clinical trials to use it for treating shock from blood loss).  However they haven't abandoned sexual arousal issues entirely, since they are beginning tests with a new compound, which I assume is similar to  Bremelantide, called (for now) PL-6983.

Today there has been an update to the Bremelanotide Bulletin and also an article that mentioned Bremelanotide and PL-6983 along with other aspects of human sexuality and arousal.

This new issue of the Bremelanotide Bulletin  discusses:

    * The Bremelanotide Time Line (developments since our last issue)
    * Test Results of Bremelanotide on Iranian Men and Women
    * Current Clinical Trials including some YOU can apply to participate in
    * Other Treatments & Products for Sexual Arousal Disorder (men and women)

The complete new Bremelanotide Bulletin edition can be read here:

http://www.bremolanotide.com/bremelanotide-bulletin/2008/05/pl-6983-is-new-bremelanotide.php

And the MSNBC article, titled: "In hot pursuit of aphrodisiacs" is here:

http://bodyodd.msnbc.msn.com/archive/2008/05/28/1071292.aspx

Hopefully there will be new news about Bremelanotide / PL-6983 soon, and I'll be sure to post about it here as soon as i know! 

 A Newsvine column about Bremelanotide has a good summary of a Urology Times article that covers a recent las Vegas convention where Bremolanotide was presented by one of the researchers.

Well worth a read and especially because the researcher indicates Brem MIGHT be available in late 2007 or early 2008, which is a year or so earlier than some of the other FDA approval dates I've seen.

 …unless the FDA traditionally takes a LONG time to approve drugs after they've been independently tested, and he was saying Brem will be sent to the FDA for approval around that time – but it may still be a long time after that that we might see it available by prescription or whatever.

Check out the Newsvine article / summary about Bremelanotide here or the entire Urology Times article about the Las Vegas convention here.
 

Last week or so, the Bremelanotide Bulletin posted new results for post-menopausal women with FSD (female sexual disorder – and it's also being tested on men with erectile disorder too) as well as some new info for the previous results with pre-menopausal women.

It all looks VERY good ! 

Along with some great quotes by the women who tested Bremelanotide (formerly PT-141 and being developed by Palatin Technologies), including a chart or two, there's some additional content like a link to an ABC News article and accompanying video too!  Plus there is some information about a new study on the effects of male pheromones onwomen. Nothing ground breaking there as similar studies have pretty much showed the same thing – although not all scientists are 100% convinced.

Check it out  – > Click here for the Bremelanotide Report for this month.

Well, I was hopeful Bremelanotide worked on women as well as it did on men (it was discovered to work on men first, by accident)…. and the latest results have convinced me that it definitely works on women too!

I've read the results from both premenopausal women as well as postmenopausal women, and there is a very obvious difference in arousal conditions between the women who took Bremelanotide (formerly PT 141) and those who took the placebo.

BTW, Bremolanotide is a drug treatment in the development / testing phase to treat both men with erectile dysfunction and women with female sexual arousal disorder. Palatin Technologies is the company currentlytesting this drug.

I'll find links to more information about these most recent results and post them here, as well as keep an ongoing journal to cover the progress of Bremelanotide from now, until it gets FDA approval, until it can be purchased!